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Figure 7. The phex transgenic hyp-mouse: hyp-mice with re-introduced wild-type phex genes have partially corrected mineralization phenotypes and remain hypophosphatemic. See text for a full explanation of the proposed model for the experimental observations (specifically, the subparagraph entitled ‘HYP-PHEX transgenic [partial correction of mineralization phenotype] [Global Hypothesis]’). Also refer to the Table for more details concerning the icons used to represent the diverse molecules, pathways, and tissues.
