Figure 3. Cell cycle block by anti-mitogenic signals. Anti-mitogenic signals stimulate cyclin-dependent kinase inhibitors (CDKi) such as p16^INK4a, p21^WAF1/CIP1, and p27^KIP1. Conversely, mitogenic stimulation leads to reduced levels and loss of CDKi-mediated inhibition of cyclin D1/CDK complexes.

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