CELLS AND EXTRACELLULAR MATRICES OF DENTIN AND PULP: A BIOLOGICAL BASIS FOR REPAIR AND TISSUE ENGINEERING
Michel Goldberg*
Faculté de Chirurgie Dentaire, Université Paris V-René Descartes, Groupe Matrices Extracellulaires et biominéralisations (EA 2496), 1, rue Maurice Arnoux, 92120 Montrouge, France;
Anthony J. Smith
University of Birmingham, School of Dentistry, St Chad’s Queensway, Birmingham B4 6NN, UK
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Figure 1. Rat molar. Polarized secretory odontoblasts (O) are seen in the upper right. The sub-odontoblastic layer of Höhl cells (H) is continuous with the outer part of the pulp (P). 650x.
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Figure 2. Human tooth. Reactionary dentin is delineated from the dentin by a calcio-traumatic line (arrowheads) and from the pulp by predentin and odontoblast layers. 360x.
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Figure 3. In the rat molar model, 8 days after implantation, Ca(OH)2 induces the formation of a reparative dentinal bridge. P, pulp; C, cavity. 120x.
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Figure 4. Thirty days after implantation, BSP induces the formation of a homogeneous mineralized tissue (a,b) that totally occludes the pulpal exposure (star). 360x.
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Figure 5. MEPE implantation. After 30 days, the mesial part of the pulp (P) and mesial root canal were filled with reparative dentin (arrowheads). C, cavity. G, gingiva. 10x.
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Figure 6. Structure of the reparative dentin induced by MEPE implantation. Dentin debris and remnants of agarose beads, used as carriers (arrow), are embedded in the reparative dentin that occludes the perforation. 360x.
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