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GENES AND GENE POLYMORPHISMS ASSOCIATED WITH PERIODONTAL DISEASE

University of Louisville School of Dentistry, Louisville, KY 40292, USA;

T.C. Hart

Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA, USA

View larger version (6K): [in a new window]   Figure 1. The classic relationship among phenotype, environment, and genotype. For the periodontal disease phenotype, environmental risk factors include: smoking status, plaque control, socio-economic status, diabetes, etc. G x E is the interaction between environment and genotype. * includes gene-gene interactions.

View larger version (6K): [in a new window]   Figure 2. Steps in determining a link between a polymorphism and a disease. (1) Does Polymorphism D influence Gene C functionally? (2) Does Gene C uniquely result in Defect B? (3) Does Defect B have mechanistic plausibility for Disease A?