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ORAL SEQUELAE OF HEAD AND NECK RADIOTHERAPY

¹ Department of Oral and Maxillofacial Surgery ² Department of Radiotherapy, University Hospital, PO Box 30.001, 9700 RB Groningen, the Netherlands; ³ Department of Radiation and Stress Cell Biology, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, the Netherlands

View larger version (29K): [in a new window]   Figure 1. Flow rate of parotid and submandibular-sublingual (SM/SL) saliva as a function of time after start of radiotherapy (conventional fractionation schedule, 2Gy per day, 5 days per week, total dose 60-70 Gy). The parotid, submandibular, and sublingual glands are located in the treatment portal. Initial flow rates were set to 100% (modified after Burlage et al,. 2001).

View larger version (20K): [in a new window]   Figure 2. Schematic diagram illustrating time of onset and duration of radiation-induced oral sequelae (modified after Maxymiw and Wood, 1989).