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GENETICALLY ALTERED MOUSE MODELS: THE GOOD, THE BAD, AND THE UGLY

Functional Genomics Unit and Gene Targeting Facility, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 527, 30 Convent Drive, Bethesda, MD 20892;

View larger version (67K): [in a new window]   Figure. Strategy for generation of dTGF-ß1 mice and gross tooth abnormalities in these mice. (a) Schematic representation of the TGF-ß1 transgenic construct. The transgenic construct was constructed by fusion of a 6-kb dentin sialophosphoprotein (dspp) upstream regulatory sequence with active porcine TGF-ß1 cDNA in which Cys223 and Cys225 codons are replaced with serine codons. (b) Normal maxillary and mandibular incisors in wild-type mice. (c) Loss of maxillary incisors (arrowhead,) and discolored and fractured mandibular incisors (arrows) in dTGF-ß1 mice. (d) Normal opacity in the craniofacial region of 15-day-old wild-type mice as measured by radiographic analysis. (e) Significantly reduced opacity in the incisors (arrows) and molars (arrowheads) of dTGF-ß1 mice. From Thyagarajan et al.(2001). With the permission of the Journal of Biological Chemistry.