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PROGNOSIS OF ORAL PRE-MALIGNANT LESIONS: SIGNIFICANCE OF CLINICAL, HISTOPATHOLOGICAL, AND MOLECULAR BIOLOGICAL CHARACTERISTICS

Department of Oral Pathology & Medicine, School of Dentistry, University of Copenhagen, 20 Nørre Allé, DK-2200 Copenhagen N, Denmark; jesper.reibel{at}odont.ku.dk

View larger version (121K): [in a new window]   Figure 1. Biopsy of leukoplakia in floor of mouth showing severe dysplasia/carcinoma in situ. Note normal epithelium in left side. The dysplastic area is especially characterized by an increased nuclear-cytoplasmic ratio, an increased number of mitotic figures including abnormal mitoses and mitoses occurring in the middle and upper parts of the epithelium, nuclear hyperchromatism, and enlarged nuclei. H&E, X90.

View larger version (121K): [in a new window]   Figure 2. Biopsy of leukoplakia at lateral border of the tongue showing mild to moderate epithelial dysplasia. Note normal stratification and cytology in superficial half of the epithelium. H&E, X190.

View larger version (121K): [in a new window]   Figure 3. Pyogenic (teleangiectatic) granuloma on the gingiva stained for keratin 19. Note staining in almost the entire epithelium which represents pathologically non-cornified oral gingival epithelium. In epithelial dysplasia, a staining pattern similar to this one has been reported; however, in normal oral non-cornified epithelia, keratin 19 is variably detectable in the basal cell layer only. X100.

View larger version (121K): [in a new window]   Figure 4. Biopsy of leukoplakia in floor of mouth stained for p53. Conventional histology showed moderate to severe dysplasia. Note staining in nuclei in basal and parabasal/spinous cells. X190.

View larger version (121K): [in a new window]   Figure 5. Biopsy of leukoplakia in buccal mucosa stained for keratin 8. Conventional histology showed severe dysplasia/carcinoma in situ. Note staining in almost the entire thickness of the epithelium. In normal buccal epithelium, keratin 8 is not detectable by immunohistochemistry. X150.