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DYNAMICS OF CELL INTERACTIONS AND COMMUNICATIONS DURING MELANOMA DEVELOPMENT

G. Li1,2
K. Satyamoorthy1
M. Herlyn1,*

1 The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104; and 2 Program of Cell and Molecular Biology, Biomedical Graduate Studies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104;



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  		Figure 1. Dynamic expression of cell adhesion molecules during melanoma development.

 


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  		Figure 2. Dynamics of cell interactions and communication during melanoma development. (A) In normal human skin, epidermal melanocytes interact with neighboring keratinocytes through E-cadherin and connexins. This contact-dependent interaction is required for the growth and phenotypic control of melanocytes by keratinocytes. (B) A shift of cadherin profile from E- to N- during melanoma development frees the cells from epidermal keratinocytes. (C) Melanoma cells communicate with each other through multiple adhesion or junctional receptors. Besides N-cadherin-mediated adherens junctions and connexin-mediated gap junctions, at least two other adhesion complexes, Mel-CAM and its ligand, L1-CAM and integrin {alpha}vß3, exist in melanoma, both of which are implicated in the progression of melanoma. (D) The cadherin shift confers new adhesive properties. N-cadherin-expressing melanoma cells are able to form N-cadherin-mediated adherens junction and connexin-mediated gap junction with vascular endothelial cells and with (E) fibroblasts.

 




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