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Critical Reviews in Oral Biology & Medicine, Vol 6, 119-131, Copyright © 1995 by International & American Associations for Dental Research

ARTICLES

The role of phosphotyrosine signaling pathway in a parotid gland proliferation and function

K. R. Purushotham and M. G. Humphreys-Beher
Department of Oral Biology, University of Florida, Gainesville 32610, USA.

Tyrosine phosphorylation and the intracellular signaling processes associated with it have been the focus of intense study due to its importance in the regulation of biological processes as diverse as cell proliferation and cell differentiation. While much of what we now understand has been derived from the study of cell lines and tumor cells, the salivary glands provide a model to examine the effects of tyrosine kinases and tyrosine phosphatases in a normal differentiated tissue. This review will focus, therefore, on the role tyrosine kinases and phosphatases play in inducing the transition from stasis to active proliferation and their potential role in mediating secretory function of the salivary glands.




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Journal of Dental Research ® Critical Reviews (1990-2004)
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