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Critical Reviews in Oral Biology & Medicine, Vol 5, 291-310, Copyright © 1994 by International & American Associations for Dental Research

ARTICLES

Signal transduction mechanisms in mesenchymal cells

B. S. McAllister, J. D. Walters and M. S. Olson
Department of Periodontology, Oregon Health Sciences University, Portland 97201-3097.

Mesenchymal cells are continually stimulated by a wide spectrum of biological mediators. These mediators bind to receptors on the cell surface and initiate a cascade of signaling events. The initial signal transduction pathways known to be stimulated in mesenchymal cells included phospholipase C, phospholipase D, phospholipase A2, adenylate cyclase, receptor tyrosine kinases, and receptor serine/threonine kinases. These pathways are reviewed and specific applications for therapeutic intervention in wound healing and regenerative therapy in the periodontium are discussed.




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IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
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