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Critical Reviews in Oral Biology & Medicine, Vol 4, 73-91, Copyright © 1992 by International & American Associations for Dental Research

ARTICLES

Mesoderm and jaw development in vertebrates: the role of growth factors

N. C. Milos
Department of Oral Biology, University of Alberta, Edmonton, Canada.

The head and neck arise during development as the result of a complex series of cellular and molecular interactions that begin in the fertilized egg. In this article, the role of an important class of molecules, growth factors, is examined in two main steps of the developmental sequence: the initial induction of mesoderm and the later induction of jaw cartilage and bone. The article focuses particularly on the roles of members of the transforming growth factor-beta (TGF-beta), fibroblast growth factor (FGF), and epithelial growth factor (EGF) families in these processes and current models of growth factor involvement. Possible experiments for the future are discussed.




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IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
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