Critical Reviews in Oral Biology & Medicine, Vol 2, 139-151, Copyright © 1991 by International & American Associations for Dental Research

ARTICLES

Genetic regulation of salivary proteins in rodents

E. Kousvelari and L. A. Tabak
Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.

The presence of a protein in the cell is the result of a complex pathway that is known by the term gene expression. In this article we review the existing literature on the structure and expression of representative salivary gland genes and their regulated expression during development and upon extracellular stimulation. The expression of one of the "nuclear" protooncogenes, c-fos, in rat parotid glands is also discussed. Finally, we present some suggestions for future studies that will help to understand the mechanisms leading to gene regulation in rat salivary glands.

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