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ADVERSE DRUG REACTIONS IN THE OROFACIAL REGION

Eastman Dental Institute for Oral Health Care Sciences, University College, University of London, 256 Gray’s Inn Road, London WC1X 8LD, UK;

J.-V. Bagan

Valencia University and Hospital, General Universitario de Valencia, Avenida 3 Cruces, 46014 Valencia, Spain

^* corresponding author, scully.c{at}eastman.ucl.ac.uk

A wide spectrum of drugs can sometimes give rise to numerous adverse orofacial manifestations, particularly dry mouth, taste disturbances, oral mucosal ulceration, and/or gingival swelling. There are few relevant randomized double-blind controlled studies in this field, and therefore this paper reviews the data from case reports, small series, and non-peer-reviewed reports of adverse drug reactions affecting the orofacial region (available from a MEDLINE search to April, 2003). The more common and significant adverse orofacial consequences of drug therapy are discussed.

Key words. Oral, drugs, adverse reactions, salivary, mucosa, ulcers, taste

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