| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Boston University Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Division of Oral Biology, 700 Albany Street, W-210, Boston, MA 02118;
* corresponding author, trackman{at}bu.edu
Gingival overgrowth occurs mainly as a result of certain anti-seizure, immunosuppressive, or antihypertensive drug therapies. Excess gingival tissues impede oral function and are disfiguring. Effective oral hygiene is compromised in the presence of gingival overgrowth, and it is now recognized that this may have negative implications for the systemic health of affected patients. Recent studies indicate that cytokine balances are abnormal in drug-induced forms of gingival overgrowth. Data supporting molecular and cellular characteristics that distinguish different forms of gingival overgrowth are summarized, and aspects of gingival fibroblast extracellular matrix metabolism that are unique to gingival tissues and cells are reviewed. Abnormal cytokine balances derived principally from lymphocytes and macrophages, and unique aspects of gingival extracellular matrix metabolism, are elements of a working model presented to facilitate our gaining a better understanding of mechanisms and of the tissue specificity of gingival overgrowth.
Key words. Gingival overgrowth, gingival hyperplasia, growth factors, cytokines, connective tissue, connective tissue growth factor, fibrosis
This article has been cited by other articles:
|
|
 |
|
  A. Kantarci, P. Augustin, E. Firatli, M.C. Sheff, H. Hasturk, D.T. Graves, and P.C. Trackman Apoptosis in Gingival Overgrowth Tissues J. Dent. Res., September 1, 2007; 86(9): 888 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Black Jr., A. H. Palamakumbura, M. Stan, and P. C. Trackman Tissue-specific Mechanisms for CCN2/CTGF Persistence in Fibrotic Gingiva: INTERACTIONS BETWEEN cAMP AND MAPK SIGNALING PATHWAYS, AND PROSTAGLANDIN E2-EP3 RECEPTOR MEDIATED ACTIVATION OF THE c-JUN N-TERMINAL KINASE J. Biol. Chem., May 25, 2007; 282(21): 15416 - 15429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hakkinen and A. Csiszar Hereditary Gingival Fibromatosis: Characteristics and Novel Putative Pathogenic Mechanisms J. Dent. Res., January 1, 2007; 86(1): 25 - 34. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| IADR Journals | Advances in Dental Research ® | Journal of Dental Research ® | Critical Reviews (1990-2004) |
