| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Oral and Maxillofacial Surgery 2 Department of Radiotherapy, University Hospital, PO Box 30.001, 9700 RB Groningen, the Netherlands; 3 Department of Radiation and Stress Cell Biology, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, the Netherlands
*corresponding author, A.Vissink{at}kchir.azg.nl
The location of the primary tumor or lymph node metastases dictates the inclusion of the oral cavity, salivary glands, and jaws in the radiation treatment portals for patients who have head and neck cancer. The clinical sequelae of the radiation treatment include mucositis, hyposalivation, loss of taste, osteoradionecrosis, radiation caries, and trismus. These sequelae may be dose-limiting and have a tremendous effect on the patient’s quality of life. Most treatment protocols to prevent these sequelae are still based on clinical experience, but alternatives based on fundamental basic and clinical research are becoming more and more available. Many of these alternatives either need further study before they can be incorporated into the protocols commonly used to prevent and treat the radiation-related oral sequelae or await implementation of these protocols. In this review, the various possibilities for prevention and/or treatment of radiation-induced changes in healthy oral tissues and their consequences are discussed.
Key words. Radiotherapy, mucositis, xerostomia, caries, osteoradionecrosis, prevention, treatment
This article has been cited by other articles:
|
|
 |
|
  A.D. King, A.T. Ahuja, S.-F. Leung, J. Abrigo, J.K.T. Wong, W.S. Poon, K.S. Woo, H.S. Chan, and G.M.K. Tse MR Imaging of Nonmalignant Polyps and Masses of the Nasopharynx and Sphenoid Sinus after Radiotherapy for Nasopharyngeal Carcinoma AJNR Am. J. Neuroradiol., June 1, 2008; 29(6): 1209 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Cotrim and B. J. Baum Gene Therapy: Some History, Applications, Problems, and Prospects Toxicol Pathol, January 1, 2008; 36(1): 97 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Cotrim, F. Hyodo, K.-I. Matsumoto, A. L. Sowers, J. A. Cook, B. J. Baum, M. C. Krishna, and J. B. Mitchell Differential Radiation Protection of Salivary Glands versus Tumor by Tempol with Accompanying Tissue Assessment of Tempol by Magnetic Resonance Imaging Clin. Cancer Res., August 15, 2007; 13(16): 4928 - 4933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.L. Sandow, M. Hejrat-Yazdi, and M.W. Heft Taste loss and recovery following radiation therapy. J. Dent. Res., July 1, 2006; 85(7): 608 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M.A. Lombaert, P. K. Wierenga, T. Kok, H. H. Kampinga, G. deHaan, and R. P. Coppes Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands. Clin. Cancer Res., March 15, 2006; 12(6): 1804 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Cotrim, A. L. Sowers, B. M. Lodde, J. M. Vitolo, A. Kingman, A. Russo, J. B. Mitchell, and B. J. Baum Kinetics of Tempol for Prevention of Xerostomia Following Head and Neck Irradiation in a Mouse Model Clin. Cancer Res., October 15, 2005; 11(20): 7564 - 7568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Vitolo, A. P. Cotrim, A. L. Sowers, A. Russo, R. B. Wellner, S. R. Pillemer, J. B. Mitchell, and B. J. Baum The Stable Nitroxide Tempol Facilitates Salivary Gland Protection during Head and Neck Irradiation in a Mouse Model Clin. Cancer Res., March 1, 2004; 10(5): 1807 - 1812. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| IADR Journals | Advances in Dental Research ® | Journal of Dental Research ® | Critical Reviews (1990-2004) |
