HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Grzesik, W. J. Articles by Narayanan, A.S. Search for Related Content PubMed PubMed Citation Articles by Grzesik, W. J. Articles by Narayanan, A.S.

CEMENTUM AND PERIODONTAL WOUND HEALING AND REGENERATION

¹ Dental Research Center, CB#7455, University of North Carolina, Chapel Hill, NC 27599-7455; and ² Department of Pathology, Box 357470, University of Washington School of Medicine, Seattle, WA 98195-7470;

*corresponding author, sampath{at}u.washington.edu

The extracellular matrix (ECM) of cementum resembles other mineralized tissues in composition; however, its physiology is unique, and it contains molecules that have not been detected in other tissues. Cementum components influence the activities of periodontal cells, and they manifest selectivity toward some periodontal cell types over others. In light of emerging evidence that the ECM determines how cells respond to environmental stimuli, we hypothesize that the local environment of the cementum matrix plays a pivotal role in maintaining the homeostasis of cementum under healthy conditions. The structural integrity and biochemical composition of the cementum matrix are severely compromised in periodontal disease, and the provisional matrix generated during periodontal healing is different from that of cementum. We propose that, for new cementum and attachment formation during periodontal regeneration, the local environment must be conducive for the recruitment and function of cementum-forming cells, and that the wound matrix is favorable for repair rather than regeneration. How cementum components may regulate and participate in cementum regeneration, possible new regenerative therapies using these principles, and models of cementoblastic cells are discussed.

Key words. Cementum, extracellular matrix, periodontium, periodontal regeneration, healing

This article has been cited by other articles:

				J.S. Song, A. Wlodarska, H.J. Ko, and W.J. Grzesik Targeting and Immobilization of Bioactive Peptides on Dentin Matrix J. Dent. Res., October 1, 2007; 86(10): 968 - 973. [Abstract] [Full Text] [PDF]

				D.D. Bosshardt Are Cementoblasts a Subpopulation of Osteoblasts or a Unique Phenotype? J. Dent. Res., May 1, 2005; 84(5): 390 - 406. [Abstract] [Full Text] [PDF]

				A. Mainnemare, B. Megarbane, A. Soueidan, A. Daniel, and I.L.C. Chapple Hypochlorous Acid and Taurine-N-Monochloramine in Periodontal Diseases J. Dent. Res., November 1, 2004; 83(11): 823 - 831. [Abstract] [Full Text] [PDF]