| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Critical Reviews in Oral Biology & Medicine, Vol 12, 331-349, Copyright © 2001 by International & American Associations for Dental Research
ARTICLES |
G. Embery, R. Hall, R. Waddington, D. Septier and M. Goldberg
Department of Basic Dental Science, Dental School, University of Wales College of Medicine, Cardiff, UK. g.embery@liverpool.ac.uk
The predominant proteoglycans present in predentin and dentin are the chondroitin-sulphate-rich decorin and biglycan and the keratan-sulphate-rich lumican and fibromodulin. These are small, interstitial, leucine-rich proteoglycans which have recently been shown to exist in gradients across the predentin. Antibodies recognizing chondroitin sulphate show a decreasing gradient from the pulpal aspect toward the mineralizing front, the converse being true for keratan sulphate. Antidecorin shows an increase toward the mineralization front. Evidence from biochemical, autoradiographic, and immunohistochemical studies implies that such changes may be brought about by gradients of metalloproteinases. This offers the possibility that the proteoglycans organize the collagen network for receipt of phosphoproteins and phospholipids, the former being evident only at the onset of dentin formation. The suggestion is raised that glycosaminoglycan-depleted leucine-rich protein cores act as sequester points for receipt of phosphoproteins in particular. The rigid, spatially oriented glycosaminoglycan chains on decorin and biglycan are known to bind calcium and may feature directly in mineral initiation.
This article has been cited by other articles:
|
|
 |
|
  A. Mazzoni, F. Mannello, F.R. Tay, G.A.M. Tonti, S. Papa, G. Mazzotti, R. Di Lenarda, D.H. Pashley, and L. Breschi Zymographic Analysis and Characterization of MMP-2 and -9 Forms in Human Sound Dentin J. Dent. Res., May 1, 2007; 86(5): 436 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mazzoni, F. Mannello, F.R. Tay, G.A.M. Tonti, S. Papa, G. Mazzotti, R. Di Lenarda, D.H. Pashley, and L. Breschi Zymographic Analysis and Characterization of MMP-2 and -9 Forms in Human Sound Dentin Journal of Dental Research, May 1, 2007; 86(5): 436 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Goldberg, D. Septier, A. Oldberg, M. F. Young, and L. G. Ameye Fibromodulin-deficient Mice Display Impaired Collagen Fibrillogenesis in Predentin as Well as Altered Dentin Mineralization and Enamel Formation J. Histochem. Cytochem., May 1, 2006; 54(5): 525 - 537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chaussain-Miller, F. Fioretti, M. Goldberg, and S. Menashi The Role of Matrix Metalloproteinases (MMPs) in Human Caries J. Dent. Res., January 1, 2006; 85(1): 22 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chaussain-Miller, F. Fioretti, M. Goldberg, and S. Menashi The Role of Matrix Metalloproteinases (MMPs) in Human Caries Journal of Dental Research, January 1, 2006; 85(1): 22 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Jiang, X.-Y. Liu, G. Zhang, and Y. Li Kinetics and Template Nucleation of Self-Assembled Hydroxyapatite Nanocrystallites by Chondroitin Sulfate J. Biol. Chem., December 23, 2005; 280(51): 42061 - 42066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.D. Bosshardt Are Cementoblasts a Subpopulation of Osteoblasts or a Unique Phenotype? J. Dent. Res., May 1, 2005; 84(5): 390 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.D. Bosshardt Are Cementoblasts a Subpopulation of Osteoblasts or a Unique Phenotype? Journal of Dental Research, May 1, 2005; 84(5): 390 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamakoshi, J. C-C. Hu, M. Fukae, T. Iwata, J.-W. Kim, H. Zhang, and J. P. Simmer Porcine Dentin Sialoprotein Is a Proteoglycan with Glycosaminoglycan Chains Containing Chondroitin 6-Sulfate J. Biol. Chem., January 14, 2005; 280(2): 1552 - 1560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Challacombe and R. Waddington Professor Graham Embery IADR President, 2001-2002 J. Dent. Res., October 1, 2003; 82(10): 856 - 856. [Full Text] [PDF]
|
|
|
|
|
|
S. Challacombe and R. Waddington Professor Graham Embery IADR President, 2001-2002 Journal of Dental Research, October 1, 2003; 82(10): 856 - 856. [Full Text] [PDF]
|
|
|
|
|
|
T. Sreenath, T. Thyagarajan, B. Hall, G. Longenecker, R. D'Souza, S. Hong, J. T. Wright, M. MacDougall, J. Sauk, and A. B. Kulkarni Dentin Sialophosphoprotein Knockout Mouse Teeth Display Widened Predentin Zone and Develop Defective Dentin Mineralization Similar to Human Dentinogenesis Imperfecta Type III J. Biol. Chem., June 27, 2003; 278(27): 24874 - 24880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Goldberg, D. Septier, O. Rapoport, M. Young, and L. Ameye Biglycan is a Repressor of Amelogenin Expression and Enamel Formation: An Emerging Hypothesis J. Dent. Res., August 1, 2002; 81(8): 520 - 524. [Full Text] [PDF]
|
|
|
|
|
|
M. Goldberg, D. Septier, O. Rapoport, M. Young, and L. Ameye Biglycan is a Repressor of Amelogenin Expression and Enamel Formation: An Emerging Hypothesis Journal of Dental Research, August 1, 2002; 81(8): 520 - 524. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Goldberg and D. Septier PHOSPHOLIPIDS IN AMELOGENESIS AND DENTINOGENESIS Crit. Rev. Oral. Biol. Med., May 1, 2002; 13(3): 276 - 290. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Goldberg and D. Septier PHOSPHOLIPIDS IN AMELOGENESIS AND DENTINOGENESIS Critical Reviews in Oral Biology & Medicine, May 1, 2002; 13(3): 276 - 290. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| IADR Journals | Advances in Dental Research ® | Journal of Dental Research ® | Critical Reviews (1990-2004) |
