Figure 3. Normal physiology. A scheme representing the proposed dynamic and interactive roles of PHEX, FGF23, MEPE, and matrix proteins in maintaining normal tooth-bone-renal-mineralization and phosphate homeostasis. See text for detailed description (specifically, the subparagraph entitled ‘Normal Physiology [Global Hypothesis]’). Also refer to the Table for more details concerning the icons used to represent the diverse molecules, pathways, and tissues.