Figure 6. A hypothetical model of Porphyromonas gingivalis LPS signaling via CD14 and TLR4 in gingival fibroblasts. The diagram shows the signaling cascade from the binding of the signaling complex to CD14 or TLR4 to the activation of NF-B and AP-1. P.g. LPS, Porphyromonas gingivalis lipopolysaccharide; TLR4, Toll-like receptor 4; MyD88, myeloid differentiation primary response gene 88; IRAK, IL-1 receptor accessory protein kinase; TRAF6, TNF receptor-associated factor; TAK1, transforming growth factor-ß-activated kinase1; TAB1, TAK1 binding protein1; MAPKK, map kinase kinase; AP-1, activating protein-1; JNK/p38, Jun N-terminal kinase/p38; NIK, NF-B-inducing kinase; IKK, inhibitor of nuclear factor-B; NF-B, nuclear factor-B.