Figure 2. Mitogen-activated G1 transition to the S phase. Mitogen stimulation leads to cyclin D1 synthesis. Together with its catalytic partners CDK4 and CDK6, cyclin D1 accelerates G1 progression by phosphorylating pRB.
Figure 2. Mitogen-activated G1 transition to the S phase. Mitogen stimulation leads to cyclin D1 synthesis. Together with its catalytic partners CDK4 and CDK6, cyclin D1 accelerates G1 progression by phosphorylating pRB.